General Information of the Compound
Compound ID
CP0396538
Compound Name
4-(furan-2-yl)-N-[2-(1H-indol-3-yl)ethyl]-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-amine
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Structure
Formula
C21H18N8O
Molecular Weight
398.43
Canonical SMILES
Cn1cc2c(n1)nc(NCCc1c[nH]c3ccccc13)n1nc(nc21)-c1ccco1
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InChI
InChI=1S/C21H18N8O/c1-28-12-15-18(26-28)25-21(29-20(15)24-19(27-29)17-7-4-10-30-17)22-9-8-13-11-23-16-6-3-2-5-14(13)16/h2-7,10-12,23H,8-9H2,1H3,(H,22,25,26)
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InChIKey
QCJSUMWNJLEJCF-UHFFFAOYSA-N
Physicochemical Property
logP
3.4069
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
101.86
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71459268
SID: 163502757
ChEMBL ID
CHEMBL2181141
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1250 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 77 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2870 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 30.9 nM
   TI
   LI
   LO
   TS