General Information of the Compound
Compound ID
CP0395580
Compound Name
N-(4-chloro-2-methylpyrazolo[3,4-d]pyrimidin-6-yl)-2-phenylacetamide
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Structure
Formula
C14H12ClN5O
Molecular Weight
301.737
Canonical SMILES
Cn1cc2c(Cl)nc(NC(=O)Cc3ccccc3)nc2n1
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InChI
InChI=1S/C14H12ClN5O/c1-20-8-10-12(15)17-14(18-13(10)19-20)16-11(21)7-9-5-3-2-4-6-9/h2-6,8H,7H2,1H3,(H,16,18,19,21)
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InChIKey
LTVNDZZYQPCVNF-UHFFFAOYSA-N
Physicochemical Property
logP
2.1979
Rotatable Bonds
3
Heavy Atom Count
21
Polar Areas
72.7
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
21

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 76317724
ChEMBL ID
CHEMBL3114163
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 16300 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 29900 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 20000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 6600 nM
   TI
   LI
   LO
   TS