General Information of the Compound
Compound ID
CP0395247
Compound Name
8-[2-(4-benzylpiperidin-1-yl)acetyl]-1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-methyl-1,3,8-triazaspiro[4.5]decane-2,4-dione
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Structure
Formula
C31H34F6N4O3
Molecular Weight
624.626
Canonical SMILES
CN1C(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C2(CCN(CC2)C(=O)CN2CCC(Cc3ccccc3)CC2)C1=O
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InChI
InChI=1S/C31H34F6N4O3/c1-38-27(43)29(41(28(38)44)19-23-16-24(30(32,33)34)18-25(17-23)31(35,36)37)9-13-40(14-10-29)26(42)20-39-11-7-22(8-12-39)15-21-5-3-2-4-6-21/h2-6,16-18,22H,7-15,19-20H2,1H3
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InChIKey
BXGTWCLBVXIHEG-UHFFFAOYSA-N
Physicochemical Property
logP
5.4341
Rotatable Bonds
6
Heavy Atom Count
44
Polar Areas
64.17
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
44

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 9809308
SID: 14765385
ChEMBL ID
CHEMBL82552
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3715.35 nM
   TI
   LI
   LO
   TS