General Information of the Compound
Compound ID
CP0395140
Compound Name
3-(1H-Indol-3-yl)-N-phenethyl-2-{2-[(pyridin-3-ylmethyl)-amino]-acetylamino}-propionamide
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Structure
Formula
C27H29N5O2
Molecular Weight
455.562
Canonical SMILES
O=C(CNCc1cccnc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1
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InChI
InChI=1S/C27H29N5O2/c33-26(19-29-17-21-9-6-13-28-16-21)32-25(15-22-18-31-24-11-5-4-10-23(22)24)27(34)30-14-12-20-7-2-1-3-8-20/h1-11,13,16,18,25,29,31H,12,14-15,17,19H2,(H,30,34)(H,32,33)
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InChIKey
CERUDGRKJUYCGK-UHFFFAOYSA-N
Physicochemical Property
logP
2.7389
Rotatable Bonds
11
Heavy Atom Count
34
Polar Areas
98.91
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44300429
ChEMBL ID
CHEMBL292176
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01996, Bombesin receptor subtype-3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 21 nM
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