General Information of the Compound
Compound ID
CP0394646
Compound Name
ethyl 2-(furan-2-yl)-5-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylate
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Structure
Formula
C21H26N6O5
Molecular Weight
442.476
Canonical SMILES
CCOC(=O)c1cnc(N2CCN(CC2)C(=O)OC(C)(C)C)n2nc(nc12)-c1ccco1
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InChI
InChI=1S/C21H26N6O5/c1-5-30-18(28)14-13-22-19(27-17(14)23-16(24-27)15-7-6-12-31-15)25-8-10-26(11-9-25)20(29)32-21(2,3)4/h6-7,12-13H,5,8-11H2,1-4H3
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InChIKey
YXUJWNZOQUFSPE-UHFFFAOYSA-N
Physicochemical Property
logP
2.6181
Rotatable Bonds
4
Heavy Atom Count
32
Polar Areas
115.3
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
10
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145987813
ChEMBL ID
CHEMBL4290655
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 100000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 100000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 30000 nM
   TI
   LI
   LO
   TS