General Information of the Compound
Compound ID
CP0394461
Compound Name
1-(4-bromophenyl)sulfonyl-5-fluoro-3-[(4-methylpiperazin-1-yl)methyl]indole
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Structure
Formula
C20H21BrFN3O2S
Molecular Weight
466.376
Canonical SMILES
CN1CCN(Cc2cn(c3ccc(F)cc23)S(=O)(=O)c2ccc(Br)cc2)CC1
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InChI
InChI=1S/C20H21BrFN3O2S/c1-23-8-10-24(11-9-23)13-15-14-25(20-7-4-17(22)12-19(15)20)28(26,27)18-5-2-16(21)3-6-18/h2-7,12,14H,8-11,13H2,1H3
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InChIKey
AZTGMNJNRFRRPC-UHFFFAOYSA-N
Physicochemical Property
logP
3.5273
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
45.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137644304
ChEMBL ID
CHEMBL4085949
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 9.2 nM
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