General Information of the Compound
Compound ID
CP0393398
Compound Name
[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 11-(hydroxyamino)-11-oxoundecanoate
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Structure
Formula
C33H39N3O8
Molecular Weight
605.688
Canonical SMILES
CCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OC(=O)CCCCCCCCCC(=O)NO)c3=O)-c2nc2ccc(O)cc12
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InChI
InChI=1S/C33H39N3O8/c1-3-21-22-16-20(37)14-15-26(22)34-30-23(21)18-36-27(30)17-25-24(31(36)40)19-43-32(41)33(25,4-2)44-29(39)13-11-9-7-5-6-8-10-12-28(38)35-42/h14-17,37,42H,3-13,18-19H2,1-2H3,(H,35,38)/t33-/m0/s1
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InChIKey
SEXLEEQQVYCAEO-XIFFEERXSA-N
Physicochemical Property
logP
4.9148
Rotatable Bonds
13
Heavy Atom Count
44
Polar Areas
157.05
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
10
Complexity
44

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145985947
ChEMBL ID
CHEMBL4242465
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00991, Histone deacetylase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4 Trichoplusia ni (Cabbage looper)  1
1
IC50 = 6180 nM
   TI
   LI
   LO
   TS
Protein ID: PT00995, Histone deacetylase 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4 Trichoplusia ni (Cabbage looper)  1
1
IC50 = 5330 nM
   TI
   LI
   LO
   TS
Protein ID: PT01213, Histone deacetylase 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4 Trichoplusia ni (Cabbage looper)  1
1
IC50 = 610 nM
   TI
   LI
   LO
   TS