General Information of the Compound
Compound ID
CP0392584
Compound Name
2-[4-[4-[[5-methyl-7-[2-[methyl(methylsulfonyl)amino]phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamide
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Structure
Formula
C28H33N7O3S
Molecular Weight
547.685
Canonical SMILES
CN(c1ccccc1-c1cc(C)c2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12)S(C)(=O)=O
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InChI
InChI=1S/C28H33N7O3S/c1-19-16-25(23-6-4-5-7-24(23)33(2)39(3,37)38)35-26(19)17-30-28(32-35)31-22-10-8-20(9-11-22)21-12-14-34(15-13-21)18-27(29)36/h4-11,16-17,21H,12-15,18H2,1-3H3,(H2,29,36)(H,31,32)
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InChIKey
IZXVMYGSHYBFKM-UHFFFAOYSA-N
Physicochemical Property
logP
3.50882
Rotatable Bonds
8
Heavy Atom Count
39
Polar Areas
125.93
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57403119
ChEMBL ID
CHEMBL1934352
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01141, Focal adhesion kinase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000928 293GT Homo sapiens (Human)  1
1
IC50 = 1230 nM
   TI
   LI
   LO
   TS
Protein ID: PT01214, Tyrosine-protein kinase JAK2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000128 TF-1 Homo sapiens (Human)  1
1
IC50 = 39 nM
   TI
   LI
   LO
   TS