General Information of the Compound
Compound ID
CP0391832
Compound Name
2-[3-[(3R,9S,12S,15R,18S,21S)-15-benzyl-18-(1H-imidazol-5-ylmethyl)-9-(1H-indol-3-ylmethyl)-2,8,11,14,17,20-hexaoxo-1,7,10,13,16,19-hexazatricyclo[19.3.0.03,7]tetracosan-12-yl]propyl]guanidine
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Structure
Formula
C42H52N12O6
Molecular Weight
820.956
Canonical SMILES
NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O
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InChI
InChI=1S/C42H52N12O6/c43-42(44)46-16-6-13-30-36(55)52-33(20-26-22-47-29-12-5-4-11-28(26)29)40(59)54-18-8-15-35(54)41(60)53-17-7-14-34(53)39(58)51-32(21-27-23-45-24-48-27)38(57)50-31(37(56)49-30)19-25-9-2-1-3-10-25/h1-5,9-12,22-24,30-35,47H,6-8,13-21H2,(H,45,48)(H,49,56)(H,50,57)(H,51,58)(H,52,55)(H4,43,44,46)/t30-,31+,32-,33-,34-,35+/m0/s1
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InChIKey
FAEZTVQVAUVPSC-JABDCJIOSA-N
Physicochemical Property
logP
0.11697
Rotatable Bonds
10
Heavy Atom Count
60
Polar Areas
263.39
Hydrogen Bond Donor Count
9
Hydrogen Bond Acceptor Count
8
Complexity
60

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137637251
ChEMBL ID
CHEMBL4060767
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01528, Melanocortin receptor 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 6000 nM
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Protein ID: PT01440, Melanocyte-stimulating hormone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 900 nM
   TI
   LI
   LO
   TS