General Information of the Compound
Compound ID
CP0389924
Compound Name
N-[(1-phenylcyclopentyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide
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Structure
Formula
C29H31N5O2
Molecular Weight
481.6
Canonical SMILES
O=C(NCC1(CCCC1)c1ccccc1)N1CCC(CC1)c1nc(no1)-c1ccc2ccccc2n1
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InChI
InChI=1S/C29H31N5O2/c35-28(30-20-29(16-6-7-17-29)23-9-2-1-3-10-23)34-18-14-22(15-19-34)27-32-26(33-36-27)25-13-12-21-8-4-5-11-24(21)31-25/h1-5,8-13,22H,6-7,14-20H2,(H,30,35)
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InChIKey
BRHTTYOSDMXFKQ-UHFFFAOYSA-N
Physicochemical Property
logP
5.6858
Rotatable Bonds
5
Heavy Atom Count
36
Polar Areas
84.15
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56668711
ChEMBL ID
CHEMBL1822295
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  2
1
IC50 = 810 nM
   TI
   LI
   LO
   TS
2
IC50 = 4500 nM
   TI
   LI
   LO
   TS