General Information of the Compound
Compound ID
CP0389922
Compound Name
N-(2-methyl-2-morpholin-4-ylpropyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide
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Structure
Formula
C25H32N6O3
Molecular Weight
464.57
Canonical SMILES
CC(C)(CNC(=O)N1CCC(CC1)c1nc(no1)-c1ccc2ccccc2n1)N1CCOCC1
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InChI
InChI=1S/C25H32N6O3/c1-25(2,31-13-15-33-16-14-31)17-26-24(32)30-11-9-19(10-12-30)23-28-22(29-34-23)21-8-7-18-5-3-4-6-20(18)27-21/h3-8,19H,9-17H2,1-2H3,(H,26,32)
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InChIKey
KCOABXIIPCULGW-UHFFFAOYSA-N
Physicochemical Property
logP
3.2846
Rotatable Bonds
5
Heavy Atom Count
34
Polar Areas
96.62
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56675420
ChEMBL ID
CHEMBL1822301
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  2
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
2
IC50 = 670 nM
   TI
   LI
   LO
   TS