General Information of the Compound
Compound ID
CP0389920
Compound Name
N-[[1-(4-methylpiperazin-1-yl)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide
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Structure
Formula
C28H37N7O2
Molecular Weight
503.651
Canonical SMILES
CN1CCN(CC1)C1(CNC(=O)N2CCC(CC2)c2nc(no2)-c2ccc3ccccc3n2)CCCC1
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InChI
InChI=1S/C28H37N7O2/c1-33-16-18-35(19-17-33)28(12-4-5-13-28)20-29-27(36)34-14-10-22(11-15-34)26-31-25(32-37-26)24-9-8-21-6-2-3-7-23(21)30-24/h2-3,6-9,22H,4-5,10-20H2,1H3,(H,29,36)
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InChIKey
SUYSCXGFAKXADD-UHFFFAOYSA-N
Physicochemical Property
logP
3.734
Rotatable Bonds
5
Heavy Atom Count
37
Polar Areas
90.63
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56675304
ChEMBL ID
CHEMBL1822452
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  2
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
2
IC50 = 510 nM
   TI
   LI
   LO
   TS