General Information of the Compound
Compound ID
CP0389918
Compound Name
N-[(1-morpholin-4-ylcycloheptyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide
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Structure
Formula
C29H38N6O3
Molecular Weight
518.662
Canonical SMILES
O=C(NCC1(CCCCCC1)N1CCOCC1)N1CCC(CC1)c1nc(no1)-c1ccc2ccccc2n1
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InChI
InChI=1S/C29H38N6O3/c36-28(30-21-29(13-5-1-2-6-14-29)35-17-19-37-20-18-35)34-15-11-23(12-16-34)27-32-26(33-38-27)25-10-9-22-7-3-4-8-24(22)31-25/h3-4,7-10,23H,1-2,5-6,11-21H2,(H,30,36)
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InChIKey
GHKXFKRCWJPUHM-UHFFFAOYSA-N
Physicochemical Property
logP
4.599
Rotatable Bonds
5
Heavy Atom Count
38
Polar Areas
96.62
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56668541
ChEMBL ID
CHEMBL1822303
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  2
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
2
IC50 = 480 nM
   TI
   LI
   LO
   TS