General Information of the Compound
Compound ID
CP0389649
Compound Name
3-[(3,4-difluorophenyl)methyl]-2-ethyl-7-piperazin-1-ylimidazo[4,5-b]pyridine
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Structure
Formula
C19H21F2N5
Molecular Weight
357.408
Canonical SMILES
CCc1nc2c(ccnc2n1Cc1ccc(F)c(F)c1)N1CCNCC1
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InChI
InChI=1S/C19H21F2N5/c1-2-17-24-18-16(25-9-7-22-8-10-25)5-6-23-19(18)26(17)12-13-3-4-14(20)15(21)11-13/h3-6,11,22H,2,7-10,12H2,1H3
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InChIKey
OJJJAXFOKIFMLF-UHFFFAOYSA-N
Physicochemical Property
logP
2.7298
Rotatable Bonds
4
Heavy Atom Count
26
Polar Areas
45.98
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145952652
ChEMBL ID
CHEMBL4166040
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 139 nM
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