General Information of the Compound
Compound ID
CP0388837
Compound Name
5-(6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yloxy)-N-(5-propan-2-yl-1,2-oxazol-3-yl)indole-1-carboxamide
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Structure
Formula
C21H20N6O3
Molecular Weight
404.43
Canonical SMILES
CC(C)c1cc(NC(=O)n2ccc3cc(Oc4ncnc5CNCc45)ccc23)no1
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InChI
InChI=1S/C21H20N6O3/c1-12(2)18-8-19(26-30-18)25-21(28)27-6-5-13-7-14(3-4-17(13)27)29-20-15-9-22-10-16(15)23-11-24-20/h3-8,11-12,22H,9-10H2,1-2H3,(H,25,26,28)
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InChIKey
BZUCTUFPZCONDQ-UHFFFAOYSA-N
Physicochemical Property
logP
4.0184
Rotatable Bonds
4
Heavy Atom Count
30
Polar Areas
107.1
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 59394521
ChEMBL ID
CHEMBL3747273
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  2
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
2
IC50 = 4.1 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 9 nM