General Information of the Compound
Compound ID
CP0388285
Compound Name
methyl 4-benzyl-1-[(3S)-3-(cyclobutanecarbonylamino)-3-[4-(trifluoromethyl)phenyl]propyl]piperidine-4-carboxylate
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Structure
Formula
C29H35F3N2O3
Molecular Weight
516.604
Canonical SMILES
COC(=O)C1(Cc2ccccc2)CCN(CC[C@H](NC(=O)C2CCC2)c2ccc(cc2)C(F)(F)F)CC1
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InChI
InChI=1S/C29H35F3N2O3/c1-37-27(36)28(20-21-6-3-2-4-7-21)15-18-34(19-16-28)17-14-25(33-26(35)23-8-5-9-23)22-10-12-24(13-11-22)29(30,31)32/h2-4,6-7,10-13,23,25H,5,8-9,14-20H2,1H3,(H,33,35)/t25-/m0/s1
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InChIKey
UBWCMWMCMLDEKJ-VWLOTQADSA-N
Physicochemical Property
logP
5.5508
Rotatable Bonds
9
Heavy Atom Count
37
Polar Areas
58.64
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46837554
SID: 99220814
ChEMBL ID
CHEMBL1170529
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 10000 nM
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