General Information of the Compound
Compound ID
CP0388127
Compound Name
2-morpholin-4-ylethyl 3-[[(E)-3-[4-(1-adamantyl)phenoxy]prop-2-enoyl]amino]benzoate
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Structure
Formula
C32H38N2O5
Molecular Weight
530.665
Canonical SMILES
O=C(Nc1cccc(c1)C(=O)OCCN1CCOCC1)\C=C\Oc1ccc(cc1)C12CC3CC(CC(C3)C1)C2
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InChI
InChI=1S/C32H38N2O5/c35-30(33-28-3-1-2-26(19-28)31(36)39-15-11-34-9-13-37-14-10-34)8-12-38-29-6-4-27(5-7-29)32-20-23-16-24(21-32)18-25(17-23)22-32/h1-8,12,19,23-25H,9-11,13-18,20-22H2,(H,33,35)/b12-8+
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InChIKey
KNKKZWPDCMPLGC-XYOKQWHBSA-N
Physicochemical Property
logP
5.1746
Rotatable Bonds
9
Heavy Atom Count
39
Polar Areas
77.1
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56967432
ChEMBL ID
CHEMBL2178399
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02791, Hypoxia-inducible factor 1-alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  1
1
IC50 = 120 nM
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