General Information of the Compound
Compound ID
CP0387750
Compound Name
CHEMBL1800788
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Formula
C21H23N7O2
Molecular Weight
405.462
Canonical SMILES
CCC1CN2C(=N1)c1[nH]c(nc1N(Cc1ccccc1)C2=O)-c1cc(OC)nn1C
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InChI
InChI=1S/C21H23N7O2/c1-4-14-12-28-19(22-14)17-20(27(21(28)29)11-13-8-6-5-7-9-13)24-18(23-17)15-10-16(30-3)25-26(15)2/h5-10,14H,4,11-12H2,1-3H3,(H,23,24)
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InChIKey
NREAVSHWXOMIDU-UHFFFAOYSA-N
Physicochemical Property
logP
2.7998
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
91.64
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
SID: 125316007
ChEMBL ID
CHEMBL1800788
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 405 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 5000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 20.4 nM
   TI
   LI
   LO
   TS
2
Ki = 3.85 nM
   TI
   LI
   LO
   TS