General Information of the Compound
Compound ID
CP0387250
Compound Name
N-[(3,4-dimethoxyphenyl)methyl]-2-(furan-2-yl)-5-(methylamino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamide
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Structure
Formula
C20H20N6O4
Molecular Weight
408.418
Canonical SMILES
CNc1ncc(C(=O)NCc2ccc(OC)c(OC)c2)c2nc(nn12)-c1ccco1
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InChI
InChI=1S/C20H20N6O4/c1-21-20-23-11-13(18-24-17(25-26(18)20)15-5-4-8-30-15)19(27)22-10-12-6-7-14(28-2)16(9-12)29-3/h4-9,11H,10H2,1-3H3,(H,21,23)(H,22,27)
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InChIKey
CJWPDQKJIQQPSQ-UHFFFAOYSA-N
Physicochemical Property
logP
2.3732
Rotatable Bonds
7
Heavy Atom Count
30
Polar Areas
115.81
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145991048
ChEMBL ID
CHEMBL4285036
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 246 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 141 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 102 nM
   TI
   LI
   LO
   TS