General Information of the Compound
Compound ID
CP0386507
Compound Name
3-(phenylsulfonyl)-N-(pyridin-3-ylmethyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine
    Show/Hide
Structure
Formula
C19H14N6O2S2
Molecular Weight
422.495
Canonical SMILES
O=S(=O)(c1nnn2c3ccsc3c(NCc3cccnc3)nc12)c1ccccc1
    Show/Hide
InChI
InChI=1S/C19H14N6O2S2/c26-29(27,14-6-2-1-3-7-14)19-18-22-17(21-12-13-5-4-9-20-11-13)16-15(8-10-28-16)25(18)24-23-19/h1-11H,12H2,(H,21,22)
    Show/Hide
InChIKey
JOSRKQJPJLVRAI-UHFFFAOYSA-N
Physicochemical Property
logP
3.1789
Rotatable Bonds
5
Heavy Atom Count
29
Polar Areas
102.14
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 49799683
ChEMBL ID
CHEMBL1173135
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 260 nM
   TI
   LI
   LO
   TS
2
IC50 > 30 nM
   TI
   LI
   LO
   TS