General Information of the Compound
Compound ID
CP0383302
Compound Name
9-Ethyl-8-phenylethynyl-9H-purin-6-ylamine
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Synonyms
8-phenylethynyl-9-ethyladenine
9-Ethyl-8-phenylethynyl-9H-purin-6-ylamine
BDBM50102169
CHEMBL61259
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Structure
Formula
C15H13N5
Molecular Weight
263.304
Canonical SMILES
CCn1c(nc2c(N)ncnc12)C#Cc1ccccc1
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InChI
InChI=1S/C15H13N5/c1-2-20-12(9-8-11-6-4-3-5-7-11)19-13-14(16)17-10-18-15(13)20/h3-7,10H,2H2,1H3,(H2,16,17,18)
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InChIKey
AXENMZHFYBPHQF-UHFFFAOYSA-N
Physicochemical Property
logP
1.8282
Rotatable Bonds
1
Heavy Atom Count
20
Polar Areas
69.62
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
20

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44300688
ChEMBL ID
CHEMBL61259
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1280 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 600 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 86 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( 9-Ethyl-8-phenylethynyl-9H-purin-6-ylamine )
Drug Name 9-Ethyl-8-phenylethynyl-9H-purin-6-ylamine
Target(s)
Adenosine A2a receptor (ADORA2A)
Inhibitor
Adenosine A1 receptor (ADORA1)
Inhibitor
Adenosine A3 receptor (ADORA3)
Inhibitor