General Information of the Compound
Compound ID
CP0383017
Compound Name
2-amino-6-(2-hydroxyethylamino)-4-thiophen-2-ylpyridine-3,5-dicarbonitrile
    Show/Hide
Structure
Formula
C13H11N5OS
Molecular Weight
285.332
Canonical SMILES
Nc1nc(NCCO)c(C#N)c(-c2cccs2)c1C#N
    Show/Hide
InChI
InChI=1S/C13H11N5OS/c14-6-8-11(10-2-1-5-20-10)9(7-15)13(17-3-4-19)18-12(8)16/h1-2,5,19H,3-4H2,(H3,16,17,18)
    Show/Hide
InChIKey
WCIVZDIGPVNRFS-UHFFFAOYSA-N
Physicochemical Property
logP
1.53986
Rotatable Bonds
4
Heavy Atom Count
20
Polar Areas
118.75
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
20

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 155547715
ChEMBL ID
CHEMBL4535486
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 324 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS