General Information of the Compound
Compound ID
CP0382009
Compound Name
17beta-Hydroxy-11beta-[4-(2-methoxycarbonyl-N-methylethylamino)-phenyl]-17alpha-(1-propinyl)-estra-4,9-dien-3-one
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Structure
Formula
C32H39NO4
Molecular Weight
501.667
Canonical SMILES
COC(=O)CCN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
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InChI
InChI=1S/C32H39NO4/c1-5-16-32(36)17-14-28-26-12-8-22-19-24(34)11-13-25(22)30(26)27(20-31(28,32)2)21-6-9-23(10-7-21)33(3)18-15-29(35)37-4/h6-7,9-10,19,26-28,36H,8,11-15,17-18,20H2,1-4H3/t26-,27+,28-,31-,32-/m0/s1
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InChIKey
DNGXVLGKUPMQJT-WFZWGZKUSA-N
Physicochemical Property
logP
5.3398
Rotatable Bonds
5
Heavy Atom Count
37
Polar Areas
66.84
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25231476
SID: 57583405
ChEMBL ID
CHEMBL455175
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 0.16 nM
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