General Information of the Compound
Compound ID
CP0381884
Compound Name
9-Benzyl-8-bromo-9H-adenine
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Synonyms
56046-34-5
6-Amino-8-bromo-9-benzyl-9H-purine
8-Bromo-N9-benzyladenine
8-bromo-9-benzyladenine
9-Benzyl-8-bromo-9H-adenine
9-Benzyl-8-bromo-9H-purin-6-ylamine
9-benzyl-8-bromo-9H-purin-6-amine
9-benzyl-8-bromo-9H-purin-6-yl amine
9-benzyl-8-bromoadenine
BDBM50240851
CHEMBL151071
N9-benzyl-8-bromoadenine
OUPAEJUFVKPEHM-UHFFFAOYSA-N
SCHEMBL4341941
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Structure
Formula
C12H10BrN5
Molecular Weight
304.151
Canonical SMILES
Nc1ncnc2n(Cc3ccccc3)c(Br)nc12
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InChI
InChI=1S/C12H10BrN5/c13-12-17-9-10(14)15-7-16-11(9)18(12)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H2,14,15,16)
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InChIKey
OUPAEJUFVKPEHM-UHFFFAOYSA-N
Physicochemical Property
logP
2.2193
Rotatable Bonds
2
Heavy Atom Count
18
Polar Areas
69.62
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
18

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 9904551
SID: 14873960
ChEMBL ID
CHEMBL151071
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 6700 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 6100 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 30000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki >= 100000 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( 9-Benzyl-8-bromo-9H-adenine )
Drug Name 9-Benzyl-8-bromo-9H-adenine
Target(s)
Adenosine A2a receptor (ADORA2A)
Inhibitor
Adenosine A1 receptor (ADORA1)
Inhibitor