General Information of the Compound
Compound ID
CP0381882
Compound Name
2-(6-amino-8-bromo-9H-purin-9-yl)ethanol
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Synonyms
2-(6-amino-8-bromo-9H-purin-9-yl)ethanol
2-(6-amino-8-bromo-purin-9-yl)ethanol
43047-77-4
6-amino-8-bromo-9-(2-hydroxyethyl)-9H-purine
8-Bromo-9-(2-hydroxyethyl)-9H-adenine
9H-Purine-9-ethanol, 6-amino-8-bromo-
AKOS030562477
BDBM50257051
CHEMBL474058
CTK1C8207
DTXSID50659527
HPCQLQBYCLLETI-UHFFFAOYSA-N
SCHEMBL987368
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Structure
Formula
C7H8BrN5O
Molecular Weight
258.079
Canonical SMILES
Nc1ncnc2n(CCO)c(Br)nc12
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InChI
InChI=1S/C7H8BrN5O/c8-7-12-4-5(9)10-3-11-6(4)13(7)1-2-14/h3,14H,1-2H2,(H2,9,10,11)
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InChIKey
HPCQLQBYCLLETI-UHFFFAOYSA-N
Physicochemical Property
logP
0.1633
Rotatable Bonds
2
Heavy Atom Count
14
Polar Areas
89.85
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
14

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44572469
ChEMBL ID
CHEMBL474058
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1500 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 620 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2800 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 100000 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( 2-(6-amino-8-bromo-9H-purin-9-yl)ethanol )
Drug Name 2-(6-amino-8-bromo-9H-purin-9-yl)ethanol
Target(s)
Adenosine A1 receptor (ADORA1)
Inhibitor
Adenosine A2b receptor (ADORA2B)
Inhibitor
Adenosine A2a receptor (ADORA2A)
Inhibitor