General Information of the Compound
Compound ID
CP0381734
Compound Name
2-(3-((N-(4-tert-butylbenzyl)-1-(1-methyl-1H-imidazol-2-yl)methylsulfonamido)methyl)phenoxy)acetic acid
    Show/Hide
Structure
Formula
C25H31N3O5S
Molecular Weight
485.606
Canonical SMILES
Cn1ccnc1CS(=O)(=O)N(Cc1ccc(cc1)C(C)(C)C)Cc1cccc(OCC(O)=O)c1
    Show/Hide
InChI
InChI=1S/C25H31N3O5S/c1-25(2,3)21-10-8-19(9-11-21)15-28(34(31,32)18-23-26-12-13-27(23)4)16-20-6-5-7-22(14-20)33-17-24(29)30/h5-14H,15-18H2,1-4H3,(H,29,30)
    Show/Hide
InChIKey
TWMSTAGKFBLOEQ-UHFFFAOYSA-N
Physicochemical Property
logP
3.7132
Rotatable Bonds
10
Heavy Atom Count
34
Polar Areas
101.73
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 45266955
ChEMBL ID
CHEMBL556416
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05828, Prostaglandin E2 receptor EP2 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 58 nM
   TI
   LI
   LO
   TS
2
IC50 = 326 nM
   TI
   LI
   LO
   TS
Protein ID: PT04548, Prostaglandin E2 receptor EP4 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 3200 nM
   TI
   LI
   LO
   TS