General Information of the Compound
Compound ID
CP0380902
Compound Name
5-[2-oxo-2-[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]ethyl]-2-phenyl-3-propan-2-yl-1,3-thiazolidin-4-one
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Structure
Formula
C27H32N4O3S
Molecular Weight
492.645
Canonical SMILES
CC(C)N1C(SC(CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C1=O)c1ccccc1
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InChI
InChI=1S/C27H32N4O3S/c1-18(2)31-25(33)23(35-26(31)19-8-4-3-5-9-19)16-24(32)29-14-12-21(13-15-29)30-17-20-10-6-7-11-22(20)28-27(30)34/h3-11,18,21,23,26H,12-17H2,1-2H3,(H,28,34)
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InChIKey
KVNRSIQTHSNGTF-UHFFFAOYSA-N
Physicochemical Property
logP
4.4664
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
72.96
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 59554867
ChEMBL ID
CHEMBL3114681
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  2
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
2
Ki = 115 nM
   TI
   LI
   LO
   TS