General Information of the Compound
Compound ID
CP0379950
Compound Name
2-methyl-1-(naphthalen-2-ylsulfonyl)-5-(piperazin-1-yl)-2,3-dihydroquinolin-4(1H)-one
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Structure
Formula
C24H25N3O3S
Molecular Weight
435.549
Canonical SMILES
CC1CC(=O)c2c(cccc2N1S(=O)(=O)c1ccc2ccccc2c1)N1CCNCC1
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InChI
InChI=1S/C24H25N3O3S/c1-17-15-23(28)24-21(26-13-11-25-12-14-26)7-4-8-22(24)27(17)31(29,30)20-10-9-18-5-2-3-6-19(18)16-20/h2-10,16-17,25H,11-15H2,1H3
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InChIKey
GRRMTRMNWWFPBH-UHFFFAOYSA-N
Physicochemical Property
logP
3.4196
Rotatable Bonds
3
Heavy Atom Count
31
Polar Areas
69.72
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53320011
ChEMBL ID
CHEMBL1642131
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 42 nM
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