General Information of the Compound
Compound ID
CP0377165
Compound Name
(S)-3-(4-(2,6-dichlorobenzyloxy)phenyl)-2-((4R,5R)-5-(isopentylcarbamoyl)-1,3-dioxolane-4-carboxamido)propanoic acid
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Structure
Formula
C26H30Cl2N2O7
Molecular Weight
553.439
Canonical SMILES
CC(C)CCNC(=O)[C@@H]1OCO[C@H]1C(=O)N[C@@H](Cc1ccc(OCc2c(Cl)cccc2Cl)cc1)C(O)=O
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InChI
InChI=1S/C26H30Cl2N2O7/c1-15(2)10-11-29-24(31)22-23(37-14-36-22)25(32)30-21(26(33)34)12-16-6-8-17(9-7-16)35-13-18-19(27)4-3-5-20(18)28/h3-9,15,21-23H,10-14H2,1-2H3,(H,29,31)(H,30,32)(H,33,34)/t21-,22+,23+/m0/s1
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InChIKey
HJCLXKNDSZADFS-YTFSRNRJSA-N
Physicochemical Property
logP
3.5881
Rotatable Bonds
12
Heavy Atom Count
37
Polar Areas
123.19
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49865844
ChEMBL ID
CHEMBL1224047
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01186, Integrin alpha-4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 1100 nM
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