General Information of the Compound
Compound ID
CP0376407
Compound Name
5-Dimethylamino-7-diphenylacetylamino-2-(2-furyl)-[1,2,4]triazolo[1,5-a]-[1,3,5]triazine
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Structure
Formula
C24H21N7O2
Molecular Weight
439.479
Canonical SMILES
CN(C)c1nc(NC(=O)C(c2ccccc2)c2ccccc2)n2nc(nc2n1)-c1ccco1
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InChI
InChI=1S/C24H21N7O2/c1-30(2)22-27-23-25-20(18-14-9-15-33-18)29-31(23)24(28-22)26-21(32)19(16-10-5-3-6-11-16)17-12-7-4-8-13-17/h3-15,19H,1-2H3,(H,25,26,27,28,29,32)
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InChIKey
SBBSNIXRGIGYMZ-UHFFFAOYSA-N
Physicochemical Property
logP
3.6159
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
101.45
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46885547
ChEMBL ID
CHEMBL1089112
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 473 nM
   TI
   LI
   LO
   TS