General Information of the Compound
Compound ID
CP0376238
Compound Name
2-[5-(6-Chloro-imidazo[2,1-b]thiazole-5-sulfonylamino)-1H-indol-3-yl]-N,N-diethyl-2-oxo-acetamide
    Show/Hide
Structure
Formula
C19H18ClN5O4S2
Molecular Weight
479.971
Canonical SMILES
CCN(CC)C(=O)C(=O)c1c[nH]c2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
    Show/Hide
InChI
InChI=1S/C19H18ClN5O4S2/c1-3-24(4-2)17(27)15(26)13-10-21-14-6-5-11(9-12(13)14)23-31(28,29)18-16(20)22-19-25(18)7-8-30-19/h5-10,21,23H,3-4H2,1-2H3
    Show/Hide
InChIKey
SBBOTEUDTOUGQK-UHFFFAOYSA-N
Physicochemical Property
logP
3.3824
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
116.64
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 11283016
SID: 16369956
ChEMBL ID
CHEMBL175488
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 224.4 nM
   TI
   LI
   LO
   TS