General Information of the Compound
Compound ID
CP0375563
Compound Name
1-[(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-3a-yl]-3-cyclopropylurea
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Structure
Formula
C33H54N2O2
Molecular Weight
510.807
Canonical SMILES
CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)NC(=O)NC1CC1
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InChI
InChI=1S/C33H54N2O2/c1-20(2)22-12-17-33(35-28(37)34-21-8-9-21)19-18-31(6)23(27(22)33)10-11-25-30(5)15-14-26(36)29(3,4)24(30)13-16-32(25,31)7/h21-27,36H,1,8-19H2,2-7H3,(H2,34,35,37)/t22-,23+,24-,25+,26-,27+,30-,31+,32+,33-/m0/s1
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InChIKey
HPVAMTUAFQCIBN-ODLWIBRJSA-N
Physicochemical Property
logP
7.2189
Rotatable Bonds
3
Heavy Atom Count
37
Polar Areas
61.36
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
2
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44627094
SID: 87554274
ChEMBL ID
CHEMBL576520
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02509, G-protein coupled bile acid receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS