General Information of the Compound
Compound ID
CP0375380
Compound Name
N-methyl-4-[6-methyl-5-[[4-[(5R)-3-(oxan-4-yl)-2-oxo-5-phenylimidazolidin-1-yl]piperidin-1-yl]methyl]pyridin-2-yl]oxybenzamide
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Structure
Formula
C34H41N5O4
Molecular Weight
583.733
Canonical SMILES
CNC(=O)c1ccc(Oc2ccc(CN3CCC(CC3)N3[C@@H](CN(C4CCOCC4)C3=O)c3ccccc3)c(C)n2)cc1
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InChI
InChI=1S/C34H41N5O4/c1-24-27(10-13-32(36-24)43-30-11-8-26(9-12-30)33(40)35-2)22-37-18-14-29(15-19-37)39-31(25-6-4-3-5-7-25)23-38(34(39)41)28-16-20-42-21-17-28/h3-13,28-29,31H,14-23H2,1-2H3,(H,35,40)/t31-/m0/s1
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InChIKey
GXAULSHQHOUJMH-HKBQPEDESA-N
Physicochemical Property
logP
5.16422
Rotatable Bonds
8
Heavy Atom Count
43
Polar Areas
87.24
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 58835000
ChEMBL ID
CHEMBL2435843
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 1.3 nM
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