General Information of the Compound
Compound ID
CP0374434
Compound Name
(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(6-methylpyridazin-3-yl)methylamino]methyl]piperidin-1-yl]methanone
    Show/Hide
Structure
Formula
C19H21ClF2N4O
Molecular Weight
394.853
Canonical SMILES
Cc1ccc(CNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nn1
    Show/Hide
InChI
InChI=1S/C19H21ClF2N4O/c1-13-2-4-15(25-24-13)11-23-12-19(22)6-8-26(9-7-19)18(27)14-3-5-17(21)16(20)10-14/h2-5,10,23H,6-9,11-12H2,1H3
    Show/Hide
InChIKey
UDSFREKDDUDKDN-UHFFFAOYSA-N
Physicochemical Property
logP
3.31162
Rotatable Bonds
5
Heavy Atom Count
27
Polar Areas
58.12
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 10453264
SID: 15474912
ChEMBL ID
CHEMBL230961
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00819, 5-hydroxytryptamine receptor 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6 Rattus norvegicus (Rat)  1
1
EC50 = 7943.28 nM
   TI
   LI
   LO
   TS