General Information of the Compound
Compound ID
CP0374361
Compound Name
2-(benzo[b]thiophen-3-yl)-6,7-dichloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-benzo[d]imidazole
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Structure
Formula
C23H20Cl2N2O2S
Molecular Weight
459.398
Canonical SMILES
Clc1ccc2nc(-c3csc4ccccc34)n(C3CCC4(CC3)OCCO4)c2c1Cl
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InChI
InChI=1S/C23H20Cl2N2O2S/c24-17-5-6-18-21(20(17)25)27(14-7-9-23(10-8-14)28-11-12-29-23)22(26-18)16-13-30-19-4-2-1-3-15(16)19/h1-6,13-14H,7-12H2
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InChIKey
RDYLHVWDUKMTDC-UHFFFAOYSA-N
Physicochemical Property
logP
7.083
Rotatable Bonds
2
Heavy Atom Count
30
Polar Areas
36.28
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44581652
ChEMBL ID
CHEMBL459092
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02772, C5a anaphylatoxin chemotactic receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 790 nM
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