General Information of the Compound
Compound ID
CP0373908
Compound Name
5-((3aR,6aS)-5-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)octahydrocyclopenta[c]pyrrole-2-carbonyl)-4,6-dimethylpicolinonitrile
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Structure
Formula
C31H38F3N5O2
Molecular Weight
569.672
Canonical SMILES
COC[C@H](N1CCN(C[C@@H]1C)C1C[C@H]2CN(C[C@H]2C1)C(=O)c1c(C)cc(nc1C)C#N)c1ccc(cc1)C(F)(F)F
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InChI
InChI=1S/C31H38F3N5O2/c1-19-11-26(14-35)36-21(3)29(19)30(40)38-16-23-12-27(13-24(23)17-38)37-9-10-39(20(2)15-37)28(18-41-4)22-5-7-25(8-6-22)31(32,33)34/h5-8,11,20,23-24,27-28H,9-10,12-13,15-18H2,1-4H3/t20-,23-,24+,27?,28-/m0/s1
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InChIKey
UIPCWPCYJAMQNJ-CVPZMFSKSA-N
Physicochemical Property
logP
4.83332
Rotatable Bonds
6
Heavy Atom Count
41
Polar Areas
72.7
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46882072
ChEMBL ID
CHEMBL1077352
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 500 nM
   TI
   LI
   LO
   TS