General Information of the Compound
Compound ID
CP0373811
Compound Name
N-(7-benzyl-5-piperidin-1-yl-3,6,8,9-tetrahydropyrazolo[3,4-c][2,7]naphthyridin-1-yl)propanamide
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Structure
Formula
C24H30N6O
Molecular Weight
418.545
Canonical SMILES
CCC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3CN(Cc4ccccc4)CCc3c12
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InChI
InChI=1S/C24H30N6O/c1-2-20(31)25-22-21-18-11-14-29(15-17-9-5-3-6-10-17)16-19(18)24(26-23(21)28-27-22)30-12-7-4-8-13-30/h3,5-6,9-10H,2,4,7-8,11-16H2,1H3,(H2,25,26,27,28,31)
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InChIKey
DIDFCPKJAIBIBS-UHFFFAOYSA-N
Physicochemical Property
logP
3.855
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
77.15
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46887981
ChEMBL ID
CHEMBL1099123
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05288, Bombesin receptor subtype-3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000866 HEK293 AequoScreen Homo sapiens (Human)  1
1
EC50 = 123 nM
   TI
   LI
   LO
   TS
Protein ID: PT01996, Bombesin receptor subtype-3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000866 HEK293 AequoScreen Homo sapiens (Human)  1
1
EC50 = 3474 nM
   TI
   LI
   LO
   TS