General Information of the Compound
Compound ID
CP0373613
Compound Name
5-(Dimethylamino)-N-(3-{4-[4-({[5-(dimethylamino)-1-naphthyl]-sulfonyl}amino)butyl]piperazin-1-yl}-4-methoxyphenyl)naphthalene-1-sulfonamide
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Structure
Formula
C39H48N6O5S2
Molecular Weight
744.984
Canonical SMILES
COc1ccc(NS(=O)(=O)c2cccc3c(cccc23)N(C)C)cc1N1CCN(CCCCNS(=O)(=O)c2cccc3c(cccc23)N(C)C)CC1
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InChI
InChI=1S/C39H48N6O5S2/c1-42(2)34-16-8-14-32-30(34)12-10-18-38(32)51(46,47)40-22-6-7-23-44-24-26-45(27-25-44)36-28-29(20-21-37(36)50-5)41-52(48,49)39-19-11-13-31-33(39)15-9-17-35(31)43(3)4/h8-21,28,40-41H,6-7,22-27H2,1-5H3
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InChIKey
UZOCTPARSJOREP-UHFFFAOYSA-N
Physicochemical Property
logP
5.8151
Rotatable Bonds
14
Heavy Atom Count
52
Polar Areas
114.53
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
52

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49781252
SID: 103055332
ChEMBL ID
CHEMBL1256257
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 175 nM
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   LI
   LO
   TS