General Information of the Compound
Compound ID
CP0373212
Compound Name
5-(5,5-bis(3-chlorophenyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-7-yl)-1-methyl-1H-pyrrole-2-carbonitrile
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Structure
Formula
C27H19Cl2N3O2
Molecular Weight
488.374
Canonical SMILES
Cn1c(ccc1-c1ccc2NC(=O)COC(c3cccc(Cl)c3)(c3cccc(Cl)c3)c2c1)C#N
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InChI
InChI=1S/C27H19Cl2N3O2/c1-32-22(15-30)9-11-25(32)17-8-10-24-23(12-17)27(34-16-26(33)31-24,18-4-2-6-20(28)13-18)19-5-3-7-21(29)14-19/h2-14H,16H2,1H3,(H,31,33)
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InChIKey
UQOQTGNAPADHDP-UHFFFAOYSA-N
Physicochemical Property
logP
6.13118
Rotatable Bonds
3
Heavy Atom Count
34
Polar Areas
67.05
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44579838
ChEMBL ID
CHEMBL482624
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 175.1 nM
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