General Information of the Compound
Compound ID
CP0353915
Compound Name
5,6-dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one
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Structure
Formula
C19H18Cl3N3O
Molecular Weight
410.732
Canonical SMILES
Clc1ccc(CN2CCC(CC2)n2c3cc(Cl)c(Cl)cc3[nH]c2=O)cc1
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InChI
InChI=1S/C19H18Cl3N3O/c20-13-3-1-12(2-4-13)11-24-7-5-14(6-8-24)25-18-10-16(22)15(21)9-17(18)23-19(25)26/h1-4,9-10,14H,5-8,11H2,(H,23,26)
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InChIKey
LAGUDYUGRSQDKS-UHFFFAOYSA-N
Physicochemical Property
logP
5.1269
Rotatable Bonds
3
Heavy Atom Count
26
Polar Areas
41.03
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 130431397
ChEMBL ID
CHEMBL4452384
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  2
1
EC50 = 15.6 nM
   TI
   LI
   LO
   TS
2
EC50 = 2975 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 1995.26 nM