General Information of the Compound
Compound ID
CP0353636
Compound Name
2-methoxyethyl N-[3-[3-(imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamate
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Structure
Formula
C22H27N3O5S2
Molecular Weight
477.608
Canonical SMILES
COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1
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InChI
InChI=1S/C22H27N3O5S2/c1-16(2)11-19-13-20(18-6-4-5-17(12-18)14-25-8-7-23-15-25)21(31-19)32(27,28)24-22(26)30-10-9-29-3/h4-8,12-13,15-16H,9-11,14H2,1-3H3,(H,24,26)
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InChIKey
HFESWSMSQIORJK-UHFFFAOYSA-N
Physicochemical Property
logP
3.9197
Rotatable Bonds
10
Heavy Atom Count
32
Polar Areas
99.52
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145965943
ChEMBL ID
CHEMBL4210874
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01553, Type-2 angiotensin II receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 480 nM
   TI
   LI
   LO
   TS