General Information of the Compound
Compound ID
CP0353503
Compound Name
(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid
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Synonyms
(2R,3R)-APDC
(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid
(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate
(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid
(2R,4R)-APDC
169209-63-6
2R, 4R-APDC
2R, 4R-APDC monohydrate
2R,4R-APDC
4-amino-2,4-pyrrolidinedicarboxylic acid
52A
AC1NSJRT
AC1Q4UAD
AJ-85443
AKOS015854214
AKOS015916056
B6634
BDBM50052398
CHEBI:40139
CHEMBL40086
CTK0E5090
DTXSID10415500
EN300-88063
FCH3884669
GTPL1392
LY314593
MFCD16875409
MolPort-003-982-102
NCGC00025040-02
RTC-065564
SBB067830
SC-48823
SCHEMBL158843
TC-065564
ZINC32628523
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Structure
Formula
C6H10N2O4
Molecular Weight
174.156
Canonical SMILES
N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O
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InChI
InChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
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InChIKey
XZFMJVJDSYRWDQ-AWFVSMACSA-N
Physicochemical Property
logP
-1.785
Rotatable Bonds
2
Heavy Atom Count
12
Polar Areas
112.65
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Complexity
12

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5310984
SID: 15120503
ChEMBL ID
CHEMBL40086
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02446, Metabotropic glutamate receptor 4
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate )
Drug Name (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate
Target(s)
Metabotropic glutamate receptor 2 (mGluR2)
 Target Info 
Agonist