General Information of the Compound
Compound ID
CP0351408
Compound Name
1-[2-chloro-7-(oxolan-2-yl)pyrazolo[1,5-a]pyrimidin-6-yl]-3-[6-(triazol-2-yl)-5-(trifluoromethyl)pyridin-3-yl]urea
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Structure
Formula
C19H15ClF3N9O2
Molecular Weight
493.837
Canonical SMILES
FC(F)(F)c1cc(NC(=O)Nc2cnc3cc(Cl)nn3c2C2CCCO2)cnc1-n1nccn1
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InChI
InChI=1S/C19H15ClF3N9O2/c20-14-7-15-24-9-12(16(31(15)30-14)13-2-1-5-34-13)29-18(33)28-10-6-11(19(21,22)23)17(25-8-10)32-26-3-4-27-32/h3-4,6-9,13H,1-2,5H2,(H2,28,29,33)
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InChIKey
JPJNJCRHXRRUBG-UHFFFAOYSA-N
Physicochemical Property
logP
3.8727
Rotatable Bonds
4
Heavy Atom Count
34
Polar Areas
124.15
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118540215
ChEMBL ID
CHEMBL3806235
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03110, Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 = 0.094 nM
   TI
   LI
   LO
   TS