General Information of the Compound
Compound ID
CP0341667
Compound Name
3-cyclobutyl-2-[4-[[3-(2,6-dichlorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]methoxy]phenyl]benzimidazole-5-carboxylic acid
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Structure
Formula
C31H27Cl2N3O4
Molecular Weight
576.48
Canonical SMILES
CC(C)c1onc(c1COc1ccc(cc1)-c1nc2ccc(cc2n1C1CCC1)C(O)=O)-c1c(Cl)cccc1Cl
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InChI
InChI=1S/C31H27Cl2N3O4/c1-17(2)29-22(28(35-40-29)27-23(32)7-4-8-24(27)33)16-39-21-12-9-18(10-13-21)30-34-25-14-11-19(31(37)38)15-26(25)36(30)20-5-3-6-20/h4,7-15,17,20H,3,5-6,16H2,1-2H3,(H,37,38)
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InChIKey
OGVJMSLERDZYFC-UHFFFAOYSA-N
Physicochemical Property
logP
8.7907
Rotatable Bonds
8
Heavy Atom Count
40
Polar Areas
90.38
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156012783
ChEMBL ID
CHEMBL4637696
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01286, Bile acid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 = 14.4 nM
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   LI
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   TS
Protein ID: PT02378, Vitamin D3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 1104 nM
   TI
   LI
   LO
   TS