General Information of the Compound
Compound ID
CP0334669
Compound Name
5-chloro-4-[(2,6-dimethyloxan-4-yl)methylamino]-2-fluoro-N-(1,3-thiazol-2-yl)benzenesulfonamide
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Structure
Formula
C17H21ClFN3O3S2
Molecular Weight
433.958
Canonical SMILES
CC1CC(CNc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)CC(C)O1
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InChI
InChI=1S/C17H21ClFN3O3S2/c1-10-5-12(6-11(2)25-10)9-21-15-8-14(19)16(7-13(15)18)27(23,24)22-17-20-3-4-26-17/h3-4,7-8,10-12,21H,5-6,9H2,1-2H3,(H,20,22)
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InChIKey
YJQYKCOMUJMJND-UHFFFAOYSA-N
Physicochemical Property
logP
4.3519
Rotatable Bonds
6
Heavy Atom Count
27
Polar Areas
80.32
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137645197
ChEMBL ID
CHEMBL4084713
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01105, Sodium channel protein type 5 subunit alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1900 nM
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