General Information of the Compound
Compound ID
CP0333757
Compound Name
(S)-2-((S)-carboxy(2-(3-(2-chloro-6-methylphenyl)ureido)-2-naphthamido)methylamino)-3-(1H-indol-2-yl)propanoic acid
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Structure
Formula
C32H28ClN5O6
Molecular Weight
614.058
Canonical SMILES
Cc1cccc(Cl)c1NC(=O)Nc1cc2ccccc2cc1C(=O)N[C@H](N[C@@H](Cc1cc2ccccc2[nH]1)C(O)=O)C(O)=O
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InChI
InChI=1S/C32H28ClN5O6/c1-17-7-6-11-23(33)27(17)37-32(44)36-25-15-19-9-3-2-8-18(19)14-22(25)29(39)38-28(31(42)43)35-26(30(40)41)16-21-13-20-10-4-5-12-24(20)34-21/h2-15,26,28,34-35H,16H2,1H3,(H,38,39)(H,40,41)(H,42,43)(H2,36,37,44)/t26-,28-/m0/s1
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InChIKey
SYZZWSCZHRJZNU-XCZPVHLTSA-N
Physicochemical Property
logP
5.35292
Rotatable Bonds
10
Heavy Atom Count
44
Polar Areas
172.65
Hydrogen Bond Donor Count
7
Hydrogen Bond Acceptor Count
5
Complexity
44

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44560767
ChEMBL ID
CHEMBL508123
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01561, Glycogen phosphorylase, liver form
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 270 nM