General Information of the Compound
Compound ID
CP0333555
Compound Name
(9R,12R,15S)-15-(4-amino-butyl)-9-(4-hydroxy-benzyl)-12-isopropyl-6,7,8,9,11,12,14,15,17,18-decahydro-5-oxa-8,11,14,17-tetraaza-benzocyclooctadecene-10,13,16-trione
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Structure
Formula
C31H43N5O5
Molecular Weight
565.715
Canonical SMILES
CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2\C=C\CNC(=O)[C@H](CCCCN)NC1=O
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InChI
InChI=1S/C31H43N5O5/c1-21(2)28-31(40)35-25(10-5-6-16-32)29(38)34-17-7-9-23-8-3-4-11-27(23)41-19-18-33-26(30(39)36-28)20-22-12-14-24(37)15-13-22/h3-4,7-9,11-15,21,25-26,28,33,37H,5-6,10,16-20,32H2,1-2H3,(H,34,38)(H,35,40)(H,36,39)/b9-7+/t25-,26+,28+/m0/s1
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InChIKey
UGLQNSFGWCGECE-AWBUAIGWSA-N
Physicochemical Property
logP
1.8695
Rotatable Bonds
7
Heavy Atom Count
41
Polar Areas
154.81
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
7
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11994679
SID: 17493797
ChEMBL ID
CHEMBL214508
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01121, Motilin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 664 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 664 nM