General Information of the Compound
Compound ID
CP0311031
Compound Name
2-[[(3S,4R)-4-aminooxolan-3-yl]amino]-4-(3-methylanilino)pyrimidine-5-carboxamide
    Show/Hide
Structure
Formula
C16H20N6O2
Molecular Weight
328.376
Canonical SMILES
Cc1cccc(Nc2nc(N[C@@H]3COC[C@@H]3N)ncc2C(N)=O)c1
    Show/Hide
InChI
InChI=1S/C16H20N6O2/c1-9-3-2-4-10(5-9)20-15-11(14(18)23)6-19-16(22-15)21-13-8-24-7-12(13)17/h2-6,12-13H,7-8,17H2,1H3,(H2,18,23)(H2,19,20,21,22)/t12-,13+/m0/s1
    Show/Hide
InChIKey
BDGFNUAQDSGUKL-QWHCGFSZSA-N
Physicochemical Property
logP
0.76552
Rotatable Bonds
5
Heavy Atom Count
24
Polar Areas
128.18
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
7
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 56673154
ChEMBL ID
CHEMBL1835067
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 3981.07 nM
   TI
   LI
   LO
   TS