General Information of the Compound
Compound ID
CP0298531
Compound Name
(5S)-5-[(1S)-2,3-dimethylcyclohex-2-en-1-yl]-7,9-difluoro-2,2,4-trimethyl-1,5-dihydrochromeno[3,4-f]quinoline
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Structure
Formula
C27H29F2NO
Molecular Weight
421.531
Canonical SMILES
CC1=C(C)[C@H](CCC1)[C@@H]1Oc2c(F)cc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
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InChI
InChI=1S/C27H29F2NO/c1-14-7-6-8-18(16(14)3)26-24-19(20-11-17(28)12-21(29)25(20)31-26)9-10-22-23(24)15(2)13-27(4,5)30-22/h9-13,18,26,30H,6-8H2,1-5H3/t18-,26-/m0/s1
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InChIKey
KSNTUZZVDDRCSZ-QYBDOPJKSA-N
Physicochemical Property
logP
7.8092
Rotatable Bonds
1
Heavy Atom Count
31
Polar Areas
21.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44560815
ChEMBL ID
CHEMBL507532
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
EC50 = 96 nM
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