General Information of the Compound
Compound ID
CP0296303
Compound Name
2-(5-((5-(4-(trifluoromethyl)phenyl)isoxazol-3-yl)methoxy)-1H-indol-1-yl)acetic acid
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Structure
Formula
C21H15F3N2O4
Molecular Weight
416.355
Canonical SMILES
OC(=O)Cn1ccc2cc(OCc3cc(on3)-c3ccc(cc3)C(F)(F)F)ccc12
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InChI
InChI=1S/C21H15F3N2O4/c22-21(23,24)15-3-1-13(2-4-15)19-10-16(25-30-19)12-29-17-5-6-18-14(9-17)7-8-26(18)11-20(27)28/h1-10H,11-12H2,(H,27,28)
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InChIKey
GPOKBAQNQTXHEM-UHFFFAOYSA-N
Physicochemical Property
logP
4.9787
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
77.49
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 22504766
ChEMBL ID
CHEMBL393767
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00909, Peroxisome proliferator-activated receptor delta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 1390 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 31 nM